Endocrine Abstracts

GLP-1 stimulates β-cell proliferation, it also enhances the differentiation of new beta cells from progenitor cells in the pancreatic duct epithelium and it is capable of inhibiting apoptosis of β cells. GLP-1 also exhibits other effects of importance for glucose homeostasis, such as, inhibiting glucagon secretion, delaying gastric emptying, and stimulating insulin biosynthesis. These effects come along with a potential increase in peripheral insulin action. Type 2 d...

GLP-1 stimulates β-cell proliferation, it also enhances the differentiation of new beta cells from progenitor cells in the pancreatic duct epithelium and it is capable of inhibiting apoptosis of beta cells. GLP-1 also exhibits other effects of importance for glucose homeostasis, such as, inhibiting glucagon secretion, delaying gastric emptying, and stimulating insulin biosynthesis. These effects come along with a potential increase in peripheral insulin action. Type 2 dia...

Back ground: Radio iodine treatment is widely used in the management of hyperthyroidism. Recent guidelines have stressed the importance of advising patients of the recommendations with regard to radiation protection, and the implications of radioiodine treatment in relation to work, travel and contact with the family. We carried out a survey to assess our joint radioiodine clinic approach where all patients referred for treatment are assessed jointly by a consultant endocrinol...

Introduction: Phaeochromocytomas commonly present with episodes of sweating, palpitations, and hypertension. Urinary catecholamines measurement is the most common screening test for suspected phaeochromocytoma in the UK. We report a series of three cases in which the reason for hypertension and raised catecholamines was not a phaeochromocytoma and treating the underlying condition corrected the clinical and biochemical abnormality.Cases: Three patients w...

Lambda-cyhalothrin is a potent synthetic type II pyrethnoid used worldwide to control a wide range of insects in agriculture, forestry, human health, and home. The purpose of this study is to investigate the effects may occur on hematological and testicular functions by this pesticide. Two groups of wistar rats were used, the first group served as control and the second experimental was received an emulsion solution of Lambda-cyhalothrin by orale route at dose of 23 mg/kg duri...

Introduction: Short synacthen tests (SST) are widely performed as a screening test in patients with suspected hypoadrenalism. However, the timing of sampling and interpretation of cortisol levels remain a matter of controversy. Though known to be inferior to 30 min cortisol levels, some centres continue to analyse 60 min values (along with 30 min levels) to avoid resource-intensive tests like insulin stress tests and glucagon stimulation tests.Objective:...

Introduction: Riedel’s thyroiditis is a rare disorder of unknown aetiology and may be seen isolated or as a part of multifocal fibrosclerosis. Multifocal fibrosclerosis involves two or more fibrotic disorders including Riedel’s thyroiditis, retroperitoneal fibrosis, sclerosing mediastinitis, retro-orbital pseudotumour and sclerosing cholangitis. We report a case of recurrent Riedel’s thyroiditis as part of multifocal fibrosclerosis presenting with a woody neck s...

Background: Several cytokines and chemokines are released by adipose tissue and associated with insulin resistance. We investigated the systemic and in vitro release of RANTES(Regulated upon Activation Normal T-cell Expressed and Secreted), MCP-1(Monocyte Chemo-attractant Protein-1), adiponectin, leptin and IL-6 from three human adipose tissue depots and their relationship to insulin sensitivity.Methods: Fasting blood samples were taken from obese...

IntroductionWomen with Turner Syndrome (TS) have an increased risk of diabetes mellitus (DM), both types 1 and 2, and obesity is a common problem. This study aimed to characterise the relationship between markers of obesity and metabolic factors which might predispose to DM.MethodAnthropometric and fasting metabolic assessments were performed in 56 non-diabetic women with TS and 24 control women (mean±...

Introduction: Fasting during the month of Ramadan is the most observed religious practice by Muslims. Diabetes is one of the condition that exempt Muslims from fasting because of the risk of complications. The International Diabetes Federation states that high-risk patients ‘should not fast’. The objective of this study was therefore to evaluate the daily food intake during the month of Ramadan in non-fasting patients with diabetes in order to detect diet mistakes ma...